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Human papillomavirus vaccines (9-/2-valent)
Human papillomavirus belongs to the Papillomaviridae family and is a class of small non-enveloped DNA viruses that mainly cause proliferative lesions in the skin and mucosa of humans or animals. Papillomaviruses of different species have similar morphological characteristics. They are usually icosahedrons with a diameter of 52-60 nm. The core is a single copy of viral genomic DNA, and the shell is composed of the major coat protein L1 and the minor coat protein L2. Five L1 protein molecules aggregate to form a pentameric shell, and the viral shell is composed of 72 shell particles assembled in an icosahedral manner with T = 7.
Up to now, three HPV vaccine varieties based on the formation of virus-like particles (VLPs) by recombinant L1 coat protein have been launched worldwide, including the GlaxoSmithKline's bivalent HPV16/18 vaccine Cervarix as well as the quadrivalent HPV vaccine Gardasil and 9-valent HPV vaccine Gardasil9 of Merck & Co., Inc.
The HPV vaccine series products of Jiangsu Rec-Biotechnology Co., Ltd. include: 9-valent HPV vaccine (HPV types-6/11/16/18/31/33/45/52/58), bivalent HPV16/18 vaccine and bivalent HPV6/11 vaccine, all of which are currently in clinical trials. Among them, the 9-valent HPV vaccine has entered phase III clinical trial.
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Time of issue:2022-03-29 08:59:20
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